KILLING TWO BIRDS WITH ONE STONE BY ADMINISTRATION OF SOLUBLE ACE2: A PROMISING STRATEGY TO TREAT BOTH CARDIOVASCULAR DISEASES AND SARS-COV-2 INFECTION

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters host cells mainly by the angiotensin converting enzyme 2 (ACE2) receptor, which can recognize the spike (S) protein by its extracellular domain.Previously, recombinant soluble ACE2 (sACE2) has been clinically used as a therapeutic treatment for cardiovascular diseases.Recent da

Abstract Background The statistical modeling of biomedical corpora could yield integrated, coarse-to-fine views of biological phenomena that complement discoveries made from analysis of molecular sequence and profiling data.Here, the potential of such modeling is demonstrated by examining the 5,225 free-text items in the Caenorhabditis Genetic Cent

Background: Systemic sclerosis is a multi-systemic disease characterized by excessive fibrosis, inflammation, and vasculopathy.Common clinical features include skin thickening, telangiectasias, salt and pepper skin, beak-shaped Carafe nose, and microstomy.We report a case of ANA-negative systemic sclerosis in a male patient.Case illustration: Our p

Active galactic nuclei are extragalactic sources, and their relativistic hot-plasma jets are believed to be the main candidates of the cosmic-ray origin, above the so-called knee region of the cosmic-ray spectrum.Relativistic shocks, either single or multiple, have been observed or been theorized to be forming within relativistic jet channels in al